TY - JOUR
T1 - Accraspiroketides A-B, Phenylnaphthacenoid-Derived Polyketides with Unprecedented [6 + 6+6 + 6] + [5 + 5] Spiro-Architecture
AU - Maglangit, Fleurdeliz
AU - Wang, Shan
AU - Moser, Arvin
AU - Kyeremeh, Kwaku
AU - Trembleau, Laurent
AU - Zhou, Yongjun
AU - Clark, David James
AU - Tabudravu, Jioji
AU - Deng, Hai
N1 - Publisher Copyright:
© 2024 American Chemical Society and American Society of Pharmacognosy.
PY - 2024/4/26
Y1 - 2024/4/26
N2 - Two novel polyketides, accraspiroketides A (1) and B (2), which feature unprecedented [6 + 6+6 + 6] + [5 + 5] spiro chemical architectures, were isolated from Streptomyces sp. MA37 ΔaccJ mutant strain. Compounds 1-2 exhibit excellent activity against Gram-positive bacteria (MIC = 1.5-6.3 μg/mL). Notably, 1 and 2 have superior activity against clinically isolated Enterococcus faecium K60-39 (MIC = 4.0 μg/mL and 4.7 μg/mL, respectively) than ampicillin (MIC = 25 μg/mL).
AB - Two novel polyketides, accraspiroketides A (1) and B (2), which feature unprecedented [6 + 6+6 + 6] + [5 + 5] spiro chemical architectures, were isolated from Streptomyces sp. MA37 ΔaccJ mutant strain. Compounds 1-2 exhibit excellent activity against Gram-positive bacteria (MIC = 1.5-6.3 μg/mL). Notably, 1 and 2 have superior activity against clinically isolated Enterococcus faecium K60-39 (MIC = 4.0 μg/mL and 4.7 μg/mL, respectively) than ampicillin (MIC = 25 μg/mL).
UR - https://www.scopus.com/pages/publications/85189241963
U2 - 10.1021/acs.jnatprod.3c01012
DO - 10.1021/acs.jnatprod.3c01012
M3 - Article
AN - SCOPUS:85189241963
SN - 0163-3864
VL - 87
SP - 831
EP - 836
JO - Journal of Natural Products
JF - Journal of Natural Products
IS - 4
ER -