Accraspiroketides A-B, Phenylnaphthacenoid-Derived Polyketides with Unprecedented [6 + 6+6 + 6] + [5 + 5] Spiro-Architecture

Fleurdeliz Maglangit; Shan Wang; Arvin Moser; Kwaku Kyeremeh; Laurent Trembleau; Yongjun Zhou; David James Clark; Jioji Tabudravu; Hai Deng

doi:10.1021/acs.jnatprod.3c01012

Accraspiroketides A-B, Phenylnaphthacenoid-Derived Polyketides with Unprecedented [6 + 6+6 + 6] + [5 + 5] Spiro-Architecture

Fleurdeliz Maglangit
, Shan Wang
, Arvin Moser
, Kwaku Kyeremeh
, Laurent Trembleau
, Yongjun Zhou
, David James Clark
, Jioji Tabudravu
, Hai Deng

Department of Chemistry

University of the Philippines
Shandong University
Advanced Chemistry Development Inc. (ACD/Labs)
School of Natural and Computing Sciences
Shanghai Jiao Tong University
University of Edinburgh
University of Central Lancashire
University of Aberdeen

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Two novel polyketides, accraspiroketides A (1) and B (2), which feature unprecedented [6 + 6+6 + 6] + [5 + 5] spiro chemical architectures, were isolated from Streptomyces sp. MA37 ΔaccJ mutant strain. Compounds 1-2 exhibit excellent activity against Gram-positive bacteria (MIC = 1.5-6.3 μg/mL). Notably, 1 and 2 have superior activity against clinically isolated Enterococcus faecium K60-39 (MIC = 4.0 μg/mL and 4.7 μg/mL, respectively) than ampicillin (MIC = 25 μg/mL).

Original language	English
Pages (from-to)	831-836
Number of pages	6
Journal	Journal of Natural Products
Volume	87
Issue number	4
DOIs	https://doi.org/10.1021/acs.jnatprod.3c01012
Publication status	Published - 26 Apr 2024

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title = "Accraspiroketides A-B, Phenylnaphthacenoid-Derived Polyketides with Unprecedented [6 + 6+6 + 6] + [5 + 5] Spiro-Architecture",

abstract = "Two novel polyketides, accraspiroketides A (1) and B (2), which feature unprecedented [6 + 6+6 + 6] + [5 + 5] spiro chemical architectures, were isolated from Streptomyces sp. MA37 ΔaccJ mutant strain. Compounds 1-2 exhibit excellent activity against Gram-positive bacteria (MIC = 1.5-6.3 μg/mL). Notably, 1 and 2 have superior activity against clinically isolated Enterococcus faecium K60-39 (MIC = 4.0 μg/mL and 4.7 μg/mL, respectively) than ampicillin (MIC = 25 μg/mL).",

author = "Fleurdeliz Maglangit and Shan Wang and Arvin Moser and Kwaku Kyeremeh and Laurent Trembleau and Yongjun Zhou and Clark, \{David James\} and Jioji Tabudravu and Hai Deng",

note = "Publisher Copyright: {\textcopyright} 2024 American Chemical Society and American Society of Pharmacognosy.",

year = "2024",

month = apr,

day = "26",

doi = "10.1021/acs.jnatprod.3c01012",

language = "English",

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TY - JOUR

T1 - Accraspiroketides A-B, Phenylnaphthacenoid-Derived Polyketides with Unprecedented [6 + 6+6 + 6] + [5 + 5] Spiro-Architecture

AU - Maglangit, Fleurdeliz

AU - Wang, Shan

AU - Moser, Arvin

AU - Kyeremeh, Kwaku

AU - Trembleau, Laurent

AU - Zhou, Yongjun

AU - Clark, David James

AU - Tabudravu, Jioji

AU - Deng, Hai

PY - 2024/4/26

Y1 - 2024/4/26

N2 - Two novel polyketides, accraspiroketides A (1) and B (2), which feature unprecedented [6 + 6+6 + 6] + [5 + 5] spiro chemical architectures, were isolated from Streptomyces sp. MA37 ΔaccJ mutant strain. Compounds 1-2 exhibit excellent activity against Gram-positive bacteria (MIC = 1.5-6.3 μg/mL). Notably, 1 and 2 have superior activity against clinically isolated Enterococcus faecium K60-39 (MIC = 4.0 μg/mL and 4.7 μg/mL, respectively) than ampicillin (MIC = 25 μg/mL).

AB - Two novel polyketides, accraspiroketides A (1) and B (2), which feature unprecedented [6 + 6+6 + 6] + [5 + 5] spiro chemical architectures, were isolated from Streptomyces sp. MA37 ΔaccJ mutant strain. Compounds 1-2 exhibit excellent activity against Gram-positive bacteria (MIC = 1.5-6.3 μg/mL). Notably, 1 and 2 have superior activity against clinically isolated Enterococcus faecium K60-39 (MIC = 4.0 μg/mL and 4.7 μg/mL, respectively) than ampicillin (MIC = 25 μg/mL).

UR - https://www.scopus.com/pages/publications/85189241963

U2 - 10.1021/acs.jnatprod.3c01012

DO - 10.1021/acs.jnatprod.3c01012

M3 - Article

AN - SCOPUS:85189241963

SN - 0163-3864

VL - 87

SP - 831

EP - 836

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 4

ER -

Accraspiroketides A-B, Phenylnaphthacenoid-Derived Polyketides with Unprecedented [6 + 6+6 + 6] + [5 + 5] Spiro-Architecture

Abstract

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