Accraspiroketides A-B, Phenylnaphthacenoid-Derived Polyketides with Unprecedented [6 + 6+6 + 6] + [5 + 5] Spiro-Architecture

Fleurdeliz Maglangit, Shan Wang, Arvin Moser, Kwaku Kyeremeh, Laurent Trembleau, Yongjun Zhou, David James Clark, Jioji Tabudravu, Hai Deng

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Two novel polyketides, accraspiroketides A (1) and B (2), which feature unprecedented [6 + 6+6 + 6] + [5 + 5] spiro chemical architectures, were isolated from Streptomyces sp. MA37 ΔaccJ mutant strain. Compounds 1-2 exhibit excellent activity against Gram-positive bacteria (MIC = 1.5-6.3 μg/mL). Notably, 1 and 2 have superior activity against clinically isolated Enterococcus faecium K60-39 (MIC = 4.0 μg/mL and 4.7 μg/mL, respectively) than ampicillin (MIC = 25 μg/mL).

Original languageEnglish
Pages (from-to)831-836
Number of pages6
JournalJournal of Natural Products
Volume87
Issue number4
DOIs
Publication statusPublished - 26 Apr 2024

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