TY - JOUR
T1 - Ablation of Hepatic Tumors through the Use of a Novel Magnetic Nanocomposite Probe
T2 - Magnetic Characterization and Finite Element Method Analysis
AU - Konku, Yvonne
AU - Kutor, John
AU - Yaya, Abu
AU - Kan-Dapaah, Kwabena
N1 - Publisher Copyright:
© 2019 Yvonne Konku et al.
PY - 2019
Y1 - 2019
N2 - The authors recently proposed a novel system for thermoablation - based on nanoheating - that can potentially overcome limitations associated with previously reported techniques. The aim of this study was to evaluate the therapeutic performance of the system in the ablation of hepatic tissue, the most frequently ablated. A model nanocomposite system, maghemite nanoparticle-filled polydimethylsiloxane, was prepared, and its magnetic properties were studied as a function of nanoparticle concentration. On the basis of measured magnetic properties, a 3D finite element method (FEM) model was used to explore the development of temperature and thermal damage in nonperfused and fully perfused tissue using alternating magnetic field (AMF) parameters that are acceptable for human use. The FEM model was tested for its validity using an analytical model. The saturation magnetization increased to about 9% of the value of pure maghemite nanoparticles over the range of volume fraction (vol. %) between 1 and 5%. Lesion sizes were shown to be greatly affected by tissue perfusion and time. FEM predictions showed good agreement with results obtained with an analytical model to within 7%. Probes fabricated with magnetic nanocomposite can potentially be used to achieve reasonable lesion sizes in hepatic tissues using human-safe AMF parameters.
AB - The authors recently proposed a novel system for thermoablation - based on nanoheating - that can potentially overcome limitations associated with previously reported techniques. The aim of this study was to evaluate the therapeutic performance of the system in the ablation of hepatic tissue, the most frequently ablated. A model nanocomposite system, maghemite nanoparticle-filled polydimethylsiloxane, was prepared, and its magnetic properties were studied as a function of nanoparticle concentration. On the basis of measured magnetic properties, a 3D finite element method (FEM) model was used to explore the development of temperature and thermal damage in nonperfused and fully perfused tissue using alternating magnetic field (AMF) parameters that are acceptable for human use. The FEM model was tested for its validity using an analytical model. The saturation magnetization increased to about 9% of the value of pure maghemite nanoparticles over the range of volume fraction (vol. %) between 1 and 5%. Lesion sizes were shown to be greatly affected by tissue perfusion and time. FEM predictions showed good agreement with results obtained with an analytical model to within 7%. Probes fabricated with magnetic nanocomposite can potentially be used to achieve reasonable lesion sizes in hepatic tissues using human-safe AMF parameters.
UR - http://www.scopus.com/inward/record.url?scp=85063238616&partnerID=8YFLogxK
U2 - 10.1155/2019/6802125
DO - 10.1155/2019/6802125
M3 - Article
AN - SCOPUS:85063238616
SN - 1687-9503
VL - 2019
JO - Journal of Nanotechnology
JF - Journal of Nanotechnology
M1 - 6802125
ER -