TY - JOUR
T1 - A Genome-Wide Association Study of Childhood Body Fatness
AU - Warner, Erica T.
AU - Jiang, Lai
AU - Adjei, David Nana
AU - Turman, Constance
AU - Gordon, William
AU - Wang, Lu
AU - Tamimi, Rulla
AU - Kraft, Peter
AU - Lindström, Sara
N1 - Publisher Copyright:
© 2021 The Obesity Society
PY - 2021/2
Y1 - 2021/2
N2 - Objective: This study aimed to uncover genetic contributors to adiposity in early life. Methods: A genome-wide association study of childhood body fatness in 34,401 individuals within the Nurses’ Health Studies and the Health Professionals Follow-up Study was conducted. Data were imputed to the 1000 Genomes Phase 3 version 5 reference panel. Results: A total of 1,354 single-nucleotide polymorphisms (P < 10−4) were selected for replication in a previously published genome-wide association study of childhood BMI. Nineteen significant genome-wide (P < 5 × 10−8) regions were observed, fourteen of which were previously associated with childhood obesity and five were novel: BNDF (P = 7.58 × 10−13), PRKD1 (P = 1.43 × 10−10), 20p13 (P = 2.05 × 10−10), FHIT (P = 1.77 × 10−8), and LOC101927575 (P = 3.22 × 10−8). The BNDF, FHIT, and PRKD1 regions were previously associated with adult BMI. LOC101927575 and 20p13 regions have not previously been associated with adiposity phenotypes. In a transcriptome-wide analysis, associations for POMC at 2p23.3 (P = 3.36 × 10−6) and with TMEM18 at 2p25.3 (P = 3.53 × 10−7) were observed. Childhood body fatness was genetically correlated with hip (rg= 0.42, P = 4.44 × 10−16) and waist circumference (rg= 0.39, P = 5.56 × 10−16), as well as age at menarche (rg= −0.37, P = 7.96 × 10−19). Conclusions: Additional loci that contribute to childhood adiposity were identified, further explicating its genetic architecture.
AB - Objective: This study aimed to uncover genetic contributors to adiposity in early life. Methods: A genome-wide association study of childhood body fatness in 34,401 individuals within the Nurses’ Health Studies and the Health Professionals Follow-up Study was conducted. Data were imputed to the 1000 Genomes Phase 3 version 5 reference panel. Results: A total of 1,354 single-nucleotide polymorphisms (P < 10−4) were selected for replication in a previously published genome-wide association study of childhood BMI. Nineteen significant genome-wide (P < 5 × 10−8) regions were observed, fourteen of which were previously associated with childhood obesity and five were novel: BNDF (P = 7.58 × 10−13), PRKD1 (P = 1.43 × 10−10), 20p13 (P = 2.05 × 10−10), FHIT (P = 1.77 × 10−8), and LOC101927575 (P = 3.22 × 10−8). The BNDF, FHIT, and PRKD1 regions were previously associated with adult BMI. LOC101927575 and 20p13 regions have not previously been associated with adiposity phenotypes. In a transcriptome-wide analysis, associations for POMC at 2p23.3 (P = 3.36 × 10−6) and with TMEM18 at 2p25.3 (P = 3.53 × 10−7) were observed. Childhood body fatness was genetically correlated with hip (rg= 0.42, P = 4.44 × 10−16) and waist circumference (rg= 0.39, P = 5.56 × 10−16), as well as age at menarche (rg= −0.37, P = 7.96 × 10−19). Conclusions: Additional loci that contribute to childhood adiposity were identified, further explicating its genetic architecture.
UR - http://www.scopus.com/inward/record.url?scp=85100362572&partnerID=8YFLogxK
U2 - 10.1002/oby.23070
DO - 10.1002/oby.23070
M3 - Article
C2 - 33491310
AN - SCOPUS:85100362572
SN - 1930-7381
VL - 29
SP - 446
EP - 453
JO - Obesity
JF - Obesity
IS - 2
ER -